Cognitive performance, mental fatigue, and age-related decline are increasingly understood as energy and redox problems, not simply neurotransmitter deficiencies. The brain is highly metabolically active and particularly vulnerable to oxidative stress and mitochondrial dysfunction.
Hydrogen inhalation therapy is emerging as a potential support strategy for brain energy balance and cognitive resilience.
Hydrogen and the brain: unique properties
Molecular hydrogen readily crosses the blood–brain barrier and diffuses into neural tissue. Unlike stimulants or sedatives, hydrogen does not alter neurotransmission directly. Instead, it may support neuronal function by reducing excessive oxidative stress while preserving signalling pathways essential for cognition.
Human cognitive data
In a four-week pilot study involving older women, daily hydrogen inhalation resulted in:
- Approximately 14% improvement in Mini-Mental State Examination (MMSE) scores
- Significant improvements in memory recall and word recognition
- No reported adverse effects
These findings represent some of the first human evidence suggesting hydrogen inhalation may support cognitive performance in aging populations.
Cognitive fatigue and modern stress
Beyond aging, cognitive fatigue is increasingly prevalent among high-demand professionals exposed to prolonged screen time, sleep disruption, and chronic stress. While research in younger populations is still emerging, hydrogen’s effects on redox balance and mitochondrial efficiency suggest potential relevance for mental fatigue management.
INH2ALE perspective
HEALR does not position INH2ALE as a cognitive treatment. Instead, it is positioned as support for brain energy and recovery under modern cognitive load, aligning with performance, longevity, and wellness frameworks.
References (PMID):
- Korovljev D et al. Short-term H₂ inhalation improves cognitive function in older women. 2020. PMID: 32148646
- Ohta S. 2012. PMID: 23244557